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Safety and Preliminary Activity of Naptumomab Estafenatox (NAP) and Durvalumab in Patients with Advanced or Metastatic Solid Tumors Interim Results from a Phase 1b Trial (NCT03983954)
Ravit Geva, Salomon Stemmer, Ruth Perets, Corinne Maurice-Dror, Eitan Ben-Ami, Ari Raphael, Sanjeev Kumar, Ilana Lorber, Tal Hetzroni Kedem, Scott Z Fields, Marcel Rozencweig, and Talia Golan
Tumor-targeted superantigens produce curative tumor immunity with induction of memory and demonstrated antigen spreading
Meir Azulay, Michal Shahar, Eitan Shany, Eti Elbaz, Sveta Lifshits, Marie Törngren, Adam Friedmann, Robert Kramer & Gunnar Hedlund
Published in the Journal of Translation Medicine
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Tumor Targeted Superantigen (TTS), Naptumomab Estafenatox (NAP), enhances CAR-T cells potency and can boost CAR-T efficacy against solid tumors.
Sagi Y, Pinsker M and Shahar M
Poster presentation at SITC Annual Meeting 2021
Abstract: Sagi Y, Shahar M, Pinsker M. 576 Tumor Targeted Superantigen (TTS), Naptumomab Estafenatox (NAP), enhances CAR-T cells potency and can boost CAR-T efficacy against solid tumors. Journal for ImmunoTherapy of Cancer 2021;9:doi: 10.1136/jitc-2021-SITC2021.576 –
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Selective T cell Redirection Proteins (STR) Enhance the Anti-Tumor Activity of Checkpoint Inhibitors (CPIs) and can Lead to Long-Lasting Immunity Against the Tumor.
Azulay M, Lifshits S, Shany E, Friedmann A, Hedlund G and Shahar M.
Poster presentation at SITC Annual Meeting 2019.
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Naptumomab Estafenatox induces T cell recognition, turning anti-PD-1 unresponsive “cold” tumors into “hot” responsive tumors.
Azulay M, Lifshits S, Friedmann A, Hedlund G, Törngren M, Shahar M.
Poster presentation at AACR Annual Meeting 2018.
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Abstract: Meir Azulay, Sveta Lifshits, Adam Fridman, Gunnar Hedlund, Marie Törngren, Michal Shahar. Naptumomab Estafenatox induces T cell recognition, turning anti-PD-1 unresponsive “cold” tumors into “hot” responsive tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2712.
View the abstract here